Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4558
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dc.contributor.authorTodorović, Smiljaen_US
dc.contributor.authorMilanović, Desankaen_US
dc.contributor.authorJović, Milenaen_US
dc.contributor.authorVujović, Predragen_US
dc.contributor.authorKanazir, Selmaen_US
dc.contributor.authorMladenović,Aleksandraen_US
dc.contributor.authorPrvulović, Milicaen_US
dc.date.accessioned2022-03-24T17:04:17Z-
dc.date.available2022-03-24T17:04:17Z-
dc.date.issued2022-06-
dc.identifier.citationMilica Prvulovic, Smilja Todorovic, Desanka Milanovic, Milena Jovic, Predrag Vujovic, Selma Kanazir, Aleksandra Mladenovic, Calorie restriction changes the anxiety-like behaviour of ageing male Wistar rats in an onset- and duration-dependent manner, Mechanisms of Ageing and Development, Volume 204, 2022, 111666, ISSN 0047-6374, https://doi.org/10.1016/j.mad.2022.111666.en_US
dc.identifier.issn0047-6374-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4558-
dc.description.abstractAlthough initially recognized as a universally beneficial approach for the prevention of age-related impairments, the outcome of calorie restriction (CR) is now known to depend on several factors, most notably the age of the subject at the CR commencement, and CR duration. We aimed to examine if and how CR affects anxiety-like behaviour when it is introduced at middle age and late middle age. In addition, as the dopaminergic system is one of the main neurotransmitter systems involved in controlling anxiety, we examined the expression of dopamine receptors (D1R, D2R) in the cortex, striatum, and mesencephalon of male Wistar rats of varying ages. The study was performed on rats fed ad libitum (AL) or exposed to calorie restriction (60% of AL intake). Open field and light-dark tests were used to study anxiety-like behaviour, while PCR and Western blot were used to examine the expression of dopamine receptors. Calorie restriction implemented at middle-age led to variable outcomes on anxiety-like behaviour, while CR implemented at late middle age increased anxiety and decreased the availability of D2R levels in the cortex and mesencephalon. Taken together, these results advise caution when implementing calorie restriction late in life.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMechanisms of Ageing and Developmenten_US
dc.subjectAgeingen_US
dc.subjectCalorie restrictionen_US
dc.subjectAnxietyen_US
dc.subjectDopamine receptorsen_US
dc.subjectBehaviouren_US
dc.titleCalorie restriction changes the anxiety-like behaviour of ageing male Wistar rats in an onset- and duration-dependent manneren_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.mad.2022.111666-
dc.description.rankM21en_US
dc.description.impact5.432en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.orcid0000-0002-9444-4758-
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