Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4257
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dc.contributor.authorMihaljevic, Marinaen_US
dc.contributor.authorFranic, Dusankaen_US
dc.contributor.authorSoldatovic, Ivanen_US
dc.contributor.authorLukic, Ivaen_US
dc.contributor.authorPetrovic, Sanja Andricen_US
dc.contributor.authorMirjanic, Tijanaen_US
dc.contributor.authorStankovic, Biljanaen_US
dc.contributor.authorZukic, Brankaen_US
dc.contributor.authorZeljić, Katarinaen_US
dc.contributor.authorGasic, Vladimiren_US
dc.contributor.authorNovakovic, Ivanaen_US
dc.contributor.authorPavlovic, Sonjaen_US
dc.contributor.authorAdzic, Miroslaven_US
dc.contributor.authorMaric, Nadja P.en_US
dc.date.accessioned2021-10-11T16:24:33Z-
dc.date.available2021-10-11T16:24:33Z-
dc.date.issued2021-
dc.identifier.citationMarina Mihaljevic, Dusanka Franic, Ivan Soldatovic, Iva Lukic, Sanja Andric Petrovic, Tijana Mirjanic, Biljana Stankovic, Branka Zukic, Katarina Zeljic, Vladimir Gasic, Ivana Novakovic, Sonja Pavlovic, Miroslav Adzic, Nadja P. Maric, “The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls”, Psychoneuroendocrinology, Volume 128, 2021.en_US
dc.identifier.issn0306-4530-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4257-
dc.description.abstractHypothalamic–pituitary–adrenal (HPA) axis activity mediates the relationship between childhood trauma (CT) and psychosis. The FKBP5 gene, one of the key regulators of HPA axis activity after stress exposure, has been found associated with psychosis. Allele-specific and CT related FKBP5 demethylation in intron 7 was revealed in different psychiatric disorders. However, no studies have investigated FKBP5 methylation in subjects with different genetic liability for psychosis. A total of 144 participants were included in the study: 48 patients with psychotic disorders, 50 unaffected siblings, and 46 healthy controls. CT was assessed by Childhood Trauma Questionnaire. The FKBP5 rs1360780 was genotyped and FKBP5 methylation analyses were performed using bisulfite conversion followed by Sanger sequencing at three CpG sites in intron 7. Mixed linear model was used to assess group differences depending on rs1360780 T allele and CT. Results showed a significant T allele-dependent decrease of FKBP5 methylation in patients compared to unaffected siblings and controls. Effect of interaction between T allele and CT exposure on FKBP5 demethylation was found in controls. No effect of both risk factors (T allele and CT) on FKBP5 methylation level was found in unaffected siblings. We confirmed previous evidence of the association between the FKBP5 rs1360780 T allele, CT, and decreased FKBP5 methylation in intron 7. Allele-specific FKBP5 demethylation found in patients could shed a light on altered HPA axis activity in a subgroup of patients related to stress-induced psychosis. FKBP5 methylation and potential protective mechanisms in unaffected siblings after trauma exposure require further investigation.en_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofPsychoneuroendocrinologyen_US
dc.subjectFKBP5 methylationen_US
dc.subjectPsychosisen_US
dc.subjectHPA axisen_US
dc.subjectChildhood traumaen_US
dc.subjectUnaffected siblingsen_US
dc.titleThe FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controlsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.psyneuen.2021.105205-
dc.description.rankM21en_US
dc.description.impact4,905en_US
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Genetics and Evolution-
crisitem.author.orcid0000-0002-3906-7785-
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