Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4239
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dc.contributor.authorĐukanović, Stefanaen_US
dc.contributor.authorCvetković, Stefanaen_US
dc.contributor.authorLončarević, Brankaen_US
dc.contributor.authorLješević, Marijaen_US
dc.contributor.authorNikolić, Biljanaen_US
dc.contributor.authorSimin, Natašaen_US
dc.contributor.authorBekvalac, Kristinaen_US
dc.contributor.authorKekić, Dušanen_US
dc.contributor.authorMitić-Ćulafić, Draganaen_US
dc.date.accessioned2021-10-11T14:12:48Z-
dc.date.available2021-10-11T14:12:48Z-
dc.date.issued2020-10-19-
dc.identifier.citationStefana Đukanović, Stefana Cvetković, Branka Lončarević, Marija Lješević, Biljana Nikolić, Nataša Simin, Kristina Bekvalac, Dušan Kekić, Dragana Mitić-Ɔulafić: “Antistaphylococcal and biofilm inhibitory activities of Frangula alnus bark ethyl-acetate extract”; Industrial Crops and Products, Volume 158, 2020,en_US
dc.identifier.issn0926-6690-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4239-
dc.description.abstractStaphylococcus aureus is one of the leading causative of numerous infections that is resistant to various antibiotics. Since that we are facing with a serious problem of bacterial resistance it is necessary to find a new antibacterial agents in fight with it. Frangula alnus is traditionally used plant but its antibiofilm potential is poorly investigated. The aim of the study was to investigate antibiofilm activity of F. alnus ethyl-acetate extract (FA) toward S. aureus ATCC strains and clinical isolates as well as its influence on respiration in planktonic and biofilm form. The qualitative GCxGC–MS and quantitative LC–MS/MS analysis revealed that FA extract was rich in phenols and flavonoids and emodin, chatechin, and ester 4-ethoxy benzoic acid were the most dominant components. Results obtained through microdillution assay showed that FA possesses strong antibacterial activity. Furthermore, crystal violet staining of biofilm biomass demonstrated that extract had strong effect on biofilm formation of all tested strains while effect on preformed biofilms was less pronounced. The effect on biofilm was confirmed with scanning electron microscopy where the changes in biofilm structure were noticed. The activity of extract on the consumption of O2 and production of CO2 was monitored using the Micro-Oxymax respirometer. Interestingly, respiration of the most strains was decreased in planktonic form as well as in biofilms. Results obtained in this study are a good basis for further research in order to discover the mechanism of action of the FA extract on connection between biofilm and respiration.en_US
dc.relation.ispartofIndustrial Crops and Productsen_US
dc.subjectStaphylococcus aureusen_US
dc.subjectFrangula alnusen_US
dc.subjectBiofilmen_US
dc.subjectAerobic respirationen_US
dc.subjectSEM microscopyen_US
dc.titleAntistaphylococcal and biofilm inhibitory activities of Frangula alnus bark ethyl-acetate extracten_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.indcrop.2020.113013-
dc.description.rankM21aen_US
dc.description.impact5,645en_US
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.orcid0000-0001-9214-4682-
crisitem.author.orcid0000-0003-1765-2454-
crisitem.author.orcid0000-0002-6651-6814-
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