Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4126
Title: Bis-Bibenzyls from the Liverwort Pellia endiviifolia and Their Biological Activity
Authors: Ivković, Ivana
Novaković, Miroslav
Veljić, Milan 
Mojsin, Marija
Stevanović, Milena 
Marin, Petar 
Bukvički, Danka 
Keywords: 1D and 2D NMR;Pellia endiviifolia;human glioblastoma cell line;human leukemia cell lines;human teratocarcinoma cell line;perrottetin E derivatives
Issue Date: 2021
Rank: M21
Journal: Plants
Abstract: 
Based on previous investigations where bis-bibenzyls isolated from liverworts showed various biological activities (cytotoxic, antimicrobial, and antiviral), we investigated their cytotoxic activity in several human cancer cell lines. From the methylene-chloride/methanol extract of the liverwort Pellia endiviifolia, three bis-bibenzyls of the perrottetin type were isolated, namely perrottetin E, 10'-hydroxyperrottetin E, and 10,10'-dihydroxyperrottetin E. The last two were found for the first time in this species. Their structures were resolved using 1D and 2D NMR, as well as by comparison with data in the literature. Cytotoxic activity of the isolated compounds was tested on three human leukemia cell lines, HL-60 (acute promyelocytic leukemia cells), U-937 (acute monocytic leukemia cells), and K-562 (human chronic myelogenous leukemia cells), as well as on human embryonal teratocarcinoma cell line (NT2/D1) and human glioblastoma cell lines A-172 and U-251, and compared to the previously isolated bis-bibenzyls (perrottetins) of similar structure. The isolated compounds exhibited modest activity against leukemia cells and significant activity against NT2/D1 and A-172. Overall, the most active cytotoxic compounds in this investigation were perrottetin E (1), isolated in this work from Pellia endiviifolia, and perrottetin F phenanthrene derivative (7), previously isolated from Lunularia cruciata and added for a comparison of their cytotoxic activity.
URI: https://biore.bio.bg.ac.rs/handle/123456789/4126
ISSN: 2223-7747
DOI: 10.3390/plants10061063
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