Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/4058
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dc.contributor.authorElaković, I.en_US
dc.contributor.authorBrkljačić, J.en_US
dc.contributor.authorMatić, Gordanaen_US
dc.date.accessioned2021-04-23T14:08:12Z-
dc.date.available2021-04-23T14:08:12Z-
dc.date.issued2007-
dc.identifier.issn0300-9564-
dc.identifier.issn1435-1463-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/4058-
dc.description.abstractGender-related differences in the effects of imipramine, on the protein levels of glucocorticoid receptor (GR), and heat shock proteins Hsp90 and Hsp70, as well as on dexamethasone binding to corticosteroid receptors (CRs) in the pituitary, hypothalamus, hippocampus and brain cortex of non-depressed rats were studied. Differences between female and male animals in the GR protein level in the tissues of untreated animals were not noticed. However, imipramine led to opposite changes in the cellular level of GR protein in the brain of female and male rats, as well as to gender- and tissue-specific changes in in vitro dexamethasone binding to GR and mineralocorticoid receptor (MR) in the hippocampus and brain cortex. Gender-related differences in the expression of Hsp90 and Hsp70 were noticed mainly in the hippocampus, only after imipramine treatment. The observed changes in the response of GR to imipramine suggest that this antidepressant may affect both the level of the receptor protein and the mechanisms regulating its binding ability in a gender-related manner.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Neural Transmissionen_US
dc.relation.ispartofseries114;1069-1080-
dc.titleLong-term imipramine treatment affects rat brain and pituitary corticosteroid receptors and heat shock proteins levels in a gender-specific manneren_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00702-007-0665-0-
dc.identifier.pmid17393067-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Biochemistry and Molecular Biology-
crisitem.author.orcid0000-0002-0142-1056-
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