Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/3687
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dc.contributor.authorAndjus, Pavleen_US
dc.contributor.authorKosanović, Majaen_US
dc.contributor.authorMilićević, Katarinaen_US
dc.contributor.authorGautam, Mukeshen_US
dc.contributor.authorVainio, Seppo J.en_US
dc.contributor.authorJagečić, Denisen_US
dc.contributor.authorKozlova, Elena N.en_US
dc.contributor.authorPivoriūnas, Augustasen_US
dc.contributor.authorChachques, Juan-Carlosen_US
dc.contributor.authorSakaj, Mirenaen_US
dc.contributor.authorBrunello, Giuliaen_US
dc.contributor.authorMitrecic, Dinkoen_US
dc.contributor.authorZavan, Barbaraen_US
dc.date.accessioned2020-11-26T15:52:11Z-
dc.date.available2020-11-26T15:52:11Z-
dc.date.issued2020-09-18-
dc.identifier.citationAndjus P, Kosanović M, Milićević K, Gautam M, Vainio SJ, Jagečić D, Kozlova EN, Pivoriūnas A, Chachques JC, Sakaj M, Brunello G, Mitrecic D, Zavan B. Extracellular Vesicles as Innovative Tool for Diagnosis, Regeneration and Protection against Neurological Damage. Int J Mol Sci. 2020 Sep 18;21(18):6859. doi: 10.3390/ijms21186859. PMID: 32962107; PMCID: PMC7555813.en_US
dc.identifier.issn1422-0067-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/3687-
dc.description.abstractExtracellular vesicles (EVs) have recently attracted a great deal of interest as they may represent a new biosignaling paradigm. According to the mode of biogenesis, size and composition, two broad categories of EVs have been described, exosomes and microvesicles. EVs have been shown to carry cargoes of signaling proteins, RNA species, DNA and lipids. Once released, their content is selectively taken up by near or distant target cells, influencing their behavior. Exosomes are involved in cell-cell communication in a wide range of embryonic developmental processes and in fetal-maternal communication. In the present review, an outline of the role of EVs in neural development, regeneration and diseases is presented. EVs can act as regulators of normal homeostasis, but they can also promote either neuroinflammation/degeneration or tissue repair in pathological conditions, depending on their content. Since EV molecular cargo constitutes a representation of the origin cell status, EVs can be exploited in the diagnosis of several diseases. Due to their capability to cross the blood-brain barrier (BBB), EVs not only have been suggested for the diagnosis of central nervous system disorders by means of minimally invasive procedures, i.e., "liquid biopsies", but they are also considered attractive tools for targeted drug delivery across the BBB. From the therapeutic perspective, mesenchymal stem cells (MSCs) represent one of the most promising sources of EVs. In particular, the neuroprotective properties of MSCs derived from the dental pulp are here discussed.en_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.subjectdrug deliveryen_US
dc.subjectexosomesen_US
dc.subjectmiRNAen_US
dc.subjectmicrovesiclesen_US
dc.subjectneurological disordersen_US
dc.subjectneuronal developmenten_US
dc.subjectstem cellsen_US
dc.subjecttheragnostic blood–brain barrieren_US
dc.titleExtracellular Vesicles as Innovative Tool for Diagnosis, Regeneration and Protection against Neurological Damageen_US
dc.typeArticleen_US
dc.identifier.doi10.3390/ijms21186859-
dc.identifier.pmid32962107-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.orcid0000-0002-8468-8513-
crisitem.author.orcid0000-0001-7360-6853-
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