Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/360
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dc.contributor.authorStanimirovic, Draganen_US
dc.contributor.authorZeljić, Katarinaen_US
dc.contributor.authorJankovic, Ljiljanaen_US
dc.contributor.authorMagic, Markoen_US
dc.contributor.authorHadzi-Mihajlovic, Milosen_US
dc.contributor.authorMagic, Zvonkoen_US
dc.date.accessioned2019-07-01T12:04:05Z-
dc.date.available2019-07-01T12:04:05Z-
dc.date.issued2013-10-01-
dc.identifier.issn0909-8836-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/360-
dc.description.abstractThe aim of this study was to assess whether polymorphisms in toll-like receptor (TLR) and cluster of differentiation 14 (CD14) genes are associated with oral lichen planus (OLP) risk and clinical course of the disease. The study group consisted of 101 patients with confirmed OLP and 104 healthy blood donors without systemic or oral mucosal diseases. Single nucleotide polymorphisms of TLR2 (rs3804099), TLR3 (rs3775291 and rs5743312), TLR4 (rs4986790 and rs4986791), and CD14 (rs2569190) genes were genotyped using real-time PCR or PCR-restriction fragment length polymorphism (PCR-RFLP). The rs5743312 TLR3 gene polymorphism was associated with increased OLP risk in comparison with the wild type genotype (OR = 15.984, P = 0.011). No association with OLP risk was observed for the polymorphisms studied in TLR2, TLR4 and CD14 genes or for the rs3775291 polymorphism of the TLR3 gene. The polymorphisms of the TLR3 gene were in linkage disequilibrium (D′ = 1, r2 = 0.1). Identified haplotypes were not associated with the risk of OLP. The findings of the current study suggest that the TT genotype of the rs5743312 TLR3 gene polymorphism may play a significant role in the aetiology of OLP. © 2013 Eur J Oral Sci.en_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Oral Sciencesen_US
dc.subjectCD14en_US
dc.subjectOral lichen planusen_US
dc.subjectSingle nucleotide polymorphismsen_US
dc.subjectTLRsen_US
dc.titleTLR2, TLR3, TLR4 and CD14 gene polymorphisms associated with oral lichen planus risken_US
dc.typeArticleen_US
dc.identifier.doi10.1111/eos.12074-
dc.identifier.pmid24028589-
dc.identifier.scopus2-s2.0-84883787858-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/84883787858-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Genetics and Evolution-
crisitem.author.orcid0000-0002-3906-7785-
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