Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/355
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dc.contributor.authorZeljić, Katarinaen_US
dc.contributor.authorKandolf-Sekulovic, Lidijaen_US
dc.contributor.authorSupic, Gordanaen_US
dc.contributor.authorPejovic, Jankoen_US
dc.contributor.authorNovakovic, Marijanen_US
dc.contributor.authorMijuskovic, Zeljkoen_US
dc.contributor.authorMagic, Zvonkoen_US
dc.date.accessioned2019-07-01T11:54:09Z-
dc.date.available2019-07-01T11:54:09Z-
dc.date.issued2014-01-01-
dc.identifier.issn0960-8931-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/355-
dc.description.abstractPrevious studies have reported that vitamin D receptor (VDR) gene polymorphisms are associated with the occurrence of various cancers, including melanoma. The aim of the current study was to investigate the association of VDR gene polymorphisms with melanoma risk, clinicopathological characteristics, and vitamin D levels. The study group included 117 patients (84 patients with superficial spreading melanoma and 33 patients with nodular melanoma). The control group included 122 sex-matched and age-matched healthy-blood donors of the same ethnicity. VDR gene polymorphisms FokI, EcoRV, TaqI, and ApaI were genotyped by real-time PCR. In 60 patients, the total 25-hydroxyvitamin D levels were evaluated in serum samples by direct chemiluminescence. Associations among parameters were considered to be significant if the P value was less than 0.05. Significant differences in the frequencies of VDR genotypes were observed between cases and the control group for FokI and TaqI polymorphisms (P<0.0001; P=0.005, respectively). Heterozygous Ff as well as mutant FF genotypes of the FokI polymorphism were associated with increased melanoma risk compared with the wild-type form [odds ratio (OR)=3.035, P=0.003; OR=9.276, P<0.0001, respectively]. A significantly increased melanoma risk was observed for the heterozygous Tt (OR=2.302, P=0.011) and the mutated variant tt (OR=3.697, P=0.003) of the TaqI polymorphism in comparison with the wild-type genotype. None of the polymorphisms studied was associated with clinicopathological characteristics and vitamin D serum level. Our results suggest that FokI and TaqI polymorphisms in the VDR gene may be considered as potential biomarkers for melanoma susceptibility. Low vitamin D levels in melanoma patients indicate the need for vitamin D supplementation. © 2014 Wolters Kluwer Health.en_US
dc.language.isoenen_US
dc.relation.ispartofMelanoma Researchen_US
dc.subjectmelanoma risken_US
dc.subjectsingle nucleotide polymorphismsen_US
dc.subjectVDR geneen_US
dc.subjectvitamin D levelen_US
dc.titleMelanoma risk is associated with vitamin D receptor gene polymorphismsen_US
dc.typeArticleen_US
dc.identifier.doi10.1097/CMR.0000000000000065-
dc.identifier.pmid24638155-
dc.identifier.scopus2-s2.0-84899978681-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/84899978681-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Genetics and Evolution-
crisitem.author.orcid0000-0002-3906-7785-
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