Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/343
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Magic, Marko | en_US |
dc.contributor.author | Zeljić, Katarina | en_US |
dc.contributor.author | Jovandic, Stevo | en_US |
dc.contributor.author | Stepic, Jelena | en_US |
dc.contributor.author | Pejovic, Marko | en_US |
dc.contributor.author | Colic, Snjezana | en_US |
dc.contributor.author | Magic, Zvonko | en_US |
dc.contributor.author | Supic, Gordana | en_US |
dc.date.accessioned | 2019-07-01T11:28:12Z | - |
dc.date.available | 2019-07-01T11:28:12Z | - |
dc.date.issued | 2019-06-01 | - |
dc.identifier.issn | 1432-6981 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/343 | - |
dc.description.abstract | © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Objectives: Genetic variants in the hedgehog signaling pathway and VDR gene are involved in inflammatory responses and neoplastic transformation. Current study investigated whether single-nucleotide polymorphisms in the hedgehog pathway genes PTCH1, GLI1, SMO, and VDR contribute to susceptibility to odontogenic cystic lesions, odontogenic keratocysts, or inflammatory radicular cysts. Material and methods: Current study examined polymorphisms of PTCH1 (rs357564) and PTCH1 insertion (IVS1-83), GLI1 (rs2228224, rs2228226), SMO (rs2228617), and VDR (rs2228570, rs731236, rs7975232). A case-control study was conducted on 41 keratocyst cases, 43 radicular cyst cases, and control group of 93 healthy individuals without cystic lesions, radiographically confirmed. Single-nucleotide polymorphisms were assessed by real-time and TaqMan SNP genotyping assays, while PTCH1 insertion 18 bp IVS1-83 polymorphism was determined by PCR. Results: The difference in genotype distribution between keratocyst cases and control group was observed for PTCH1 IVS1-83 and GLI1 rs2228224 polymorphism (p = 0.022, p = 0.030, respectively). Homozygous mutant GG genotype within GLI1 rs2228224 is associated with increased susceptibility for odontogenous keratocysts, with adjusted odds ratio of 4.098 (confidence interval of 1.482–11.328, p = 0.007). Conclusion: GLI1 rs2228224 and PTCH1 polymorphisms could predispose to odontogenic keratocysts. Clinical relevance: Variants in hedgehog signaling pathway genes, such as GLI1 and PTCH1, and vitamin D receptor gene, might be considered as molecular risk factors in odontogenic cystic lesions and potential targets for novel therapeutic approaches. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Clinical Oral Investigations | en_US |
dc.subject | GLI1 | en_US |
dc.subject | Hedgehog signaling | en_US |
dc.subject | Odontogenic keratocysts | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | PTCH1 | en_US |
dc.subject | Vitamin D receptor | en_US |
dc.title | Hedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesions | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1007/s00784-018-2686-5 | - |
dc.identifier.pmid | 30334169 | - |
dc.identifier.scopus | 2-s2.0-85055490930 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85055490930 | - |
dc.description.rank | M21 | - |
dc.description.impact | 3.623 | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Genetics and Evolution | - |
crisitem.author.orcid | 0000-0002-3906-7785 | - |
Appears in Collections: | Journal Article |
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