Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/343
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dc.contributor.authorMagic, Markoen_US
dc.contributor.authorZeljić, Katarinaen_US
dc.contributor.authorJovandic, Stevoen_US
dc.contributor.authorStepic, Jelenaen_US
dc.contributor.authorPejovic, Markoen_US
dc.contributor.authorColic, Snjezanaen_US
dc.contributor.authorMagic, Zvonkoen_US
dc.contributor.authorSupic, Gordanaen_US
dc.date.accessioned2019-07-01T11:28:12Z-
dc.date.available2019-07-01T11:28:12Z-
dc.date.issued2019-06-01-
dc.identifier.issn1432-6981-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/343-
dc.description.abstract© 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Objectives: Genetic variants in the hedgehog signaling pathway and VDR gene are involved in inflammatory responses and neoplastic transformation. Current study investigated whether single-nucleotide polymorphisms in the hedgehog pathway genes PTCH1, GLI1, SMO, and VDR contribute to susceptibility to odontogenic cystic lesions, odontogenic keratocysts, or inflammatory radicular cysts. Material and methods: Current study examined polymorphisms of PTCH1 (rs357564) and PTCH1 insertion (IVS1-83), GLI1 (rs2228224, rs2228226), SMO (rs2228617), and VDR (rs2228570, rs731236, rs7975232). A case-control study was conducted on 41 keratocyst cases, 43 radicular cyst cases, and control group of 93 healthy individuals without cystic lesions, radiographically confirmed. Single-nucleotide polymorphisms were assessed by real-time and TaqMan SNP genotyping assays, while PTCH1 insertion 18 bp IVS1-83 polymorphism was determined by PCR. Results: The difference in genotype distribution between keratocyst cases and control group was observed for PTCH1 IVS1-83 and GLI1 rs2228224 polymorphism (p = 0.022, p = 0.030, respectively). Homozygous mutant GG genotype within GLI1 rs2228224 is associated with increased susceptibility for odontogenous keratocysts, with adjusted odds ratio of 4.098 (confidence interval of 1.482–11.328, p = 0.007). Conclusion: GLI1 rs2228224 and PTCH1 polymorphisms could predispose to odontogenic keratocysts. Clinical relevance: Variants in hedgehog signaling pathway genes, such as GLI1 and PTCH1, and vitamin D receptor gene, might be considered as molecular risk factors in odontogenic cystic lesions and potential targets for novel therapeutic approaches.en_US
dc.language.isoenen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.subjectGLI1en_US
dc.subjectHedgehog signalingen_US
dc.subjectOdontogenic keratocystsen_US
dc.subjectPolymorphismen_US
dc.subjectPTCH1en_US
dc.subjectVitamin D receptoren_US
dc.titleHedgehog signaling pathway and vitamin D receptor gene variants as potential risk factors in odontogenic cystic lesionsen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s00784-018-2686-5-
dc.identifier.pmid30334169-
dc.identifier.scopus2-s2.0-85055490930-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85055490930-
dc.description.rankM21-
dc.description.impact3.623-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Genetics and Evolution-
crisitem.author.orcid0000-0002-3906-7785-
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