Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/3433
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dc.contributor.authorĐurašević, Sinišaen_US
dc.contributor.authorNikolić, Goranaen_US
dc.contributor.authorTodorović, Anaen_US
dc.contributor.authorDrakulić, Dunjaen_US
dc.contributor.authorPejić, Snežanaen_US
dc.contributor.authorMartinović, Vesnaen_US
dc.contributor.authorMitić-Ćulafić, Draganaen_US
dc.contributor.authorMilić, Draganaen_US
dc.contributor.authorKop, Tatjana J.en_US
dc.contributor.authorJasnić, Nebojšaen_US
dc.contributor.authorĐorđević, Jelenaen_US
dc.contributor.authorTodorović, Zoranen_US
dc.date.accessioned2020-06-03T12:21:12Z-
dc.date.available2020-06-03T12:21:12Z-
dc.date.issued2020-06-01-
dc.identifier.issn0278-6915-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/3433-
dc.description.abstractThe effects of twelve weeks of supplementation with fullerene C60 olive/coconut oil solution on a broad spectrum of parameters in rats were examined. The tissue bioaccumulation of C60 was shown to be tissue-specific, with the liver, heart, and adrenal glands being the organs of the greatest, and the kidney, brain, and spleen being the organs of the smallest accumulation. C60 did not change aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase serum activities level, nor the damage of liver cells DNA. There were no effects of fullerene on prooxidant-antioxidant balance in the liver, kidney, spleen, heart, and brain, nor any visible harmful effects on the liver, heart, aorta, spleen, kidney, and small intestine histology. Fullerene changed the gut microbiota structure towards the bacteria that ameliorate lipid homeostasis, causing a serum triglycerides concentration decrease. However, C60 significantly increased the insulin resistance, serum ascorbate oxidation, and brain malondialdehyde and advanced oxidation protein products level. The deteriorative effects of C60 on the brain and serum could be attributed to the specific physicochemical composition of these tissues, potentiating the C60 aggregation or biotransformation as the key element of its pro-oxidative action.en_US
dc.language.isoenen_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.subjectFullerene C60en_US
dc.subjectGlucose homeostasisen_US
dc.subjectGut microbiotaen_US
dc.subjectLipid homeostasisen_US
dc.subjectRatsen_US
dc.titleEffects of fullerene C60 supplementation on gut microbiota and glucose and lipid homeostasis in ratsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.fct.2020.111302-
dc.identifier.pmid32234425-
dc.identifier.scopus2-s2.0-85082680875-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85082680875-
dc.description.rankM21a-
dc.description.impact6.023-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Morphology, Systematics and Phylogeny of Animals-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.orcid0000-0003-4406-8376-
crisitem.author.orcid0000-0002-6651-6814-
crisitem.author.orcid0000-0002-6034-5145-
crisitem.author.orcid0000-0003-0333-333X-
crisitem.author.orcid0000-0002-6510-1027-
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