Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/3172
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dc.contributor.authorGavrić, Jelenaen_US
dc.contributor.authorAnđelković, Markoen_US
dc.contributor.authorTomović, Ljiljanaen_US
dc.contributor.authorProkić, Markoen_US
dc.contributor.authorDespotović, Svetlanaen_US
dc.contributor.authorGavrilović, Brankaen_US
dc.contributor.authorRadovanović, Tijanaen_US
dc.contributor.authorBorković-Mitić, Slavicaen_US
dc.contributor.authorPavlović, Slađanen_US
dc.contributor.authorSaičić, Zoricaen_US
dc.date.accessioned2019-11-05T11:37:32Z-
dc.date.available2019-11-05T11:37:32Z-
dc.date.issued2017-04-01-
dc.identifier.issn0147-6513-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/3172-
dc.description.abstract© 2016 Elsevier Inc. We investigated in the liver of dice snakes during pre- and post-hibernation changes in the following antioxidant parameters: total, manganese and copper zinc containing superoxide dismutases (Tot SOD, MnSOD, CuZn SOD, respectively), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GR) and the concentrations of total glutathione (GSH) and sulfhydryl groups (–SH). In addition, we examined the expression of phase I biotransformation enzyme cytochrome P 450 1A (CYP1A) and the activity of phase II biotransformation enzyme glutathioneS-transferase (GST), the level of lipid peroxidation (by measuring the thiobarbituric acid-reactive substances (TBARS)), cholinesterase activity (ChE) and metallothionein expression (MT). We also measured the concentrations of heavy metals, including Al, Cd, As, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb and Zn in the water and snake liver during both periods. During the post-hibernation period, the activities of Tot SOD, CuZn SOD and GST and the concentration of GSH were significantly decreased, while GSH-Px and GR activities, the concentrations of –SH groups and TBARS were significantly increased. The activities of Mn SOD, CAT and ChE, and the relative amounts of CYP1A and MT did not significantly change during the investigated periods. The observed differences in the examined parameters probably represent adaptive physiological responses to sudden changes in tissue oxygenation during arousal from hibernation. Our findings also indicate that the accumulated metals modulated the responses of the examined parameters during the investigated periods.en_US
dc.description.sponsorshipMinistry of Education, Science and Technological Development of Republic of Serbiaen_US
dc.language.isoenen_US
dc.relationMolecular and physiological biomonitoring of aerobic organisms based on the determination of biochemical biomarkers of oxidative stressen_US
dc.relation.ispartofEcotoxicology and Environmental Safetyen_US
dc.subjectDice snakeen_US
dc.subjectHeavy metalsen_US
dc.subjectHibernationen_US
dc.subjectLiveren_US
dc.subjectNatrix tessellateen_US
dc.subjectOxidative stressen_US
dc.titleOxidative stress biomarkers, cholinesterase activity and biotransformation enzymes in the liver of dice snake (Natrix tessellata Laurenti) during pre-hibernation and post-hibernation: A possible correlation with heavy metals in the environmenten_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ecoenv.2016.12.036-
dc.identifier.pmid28043034-
dc.identifier.scopus2-s2.0-85007496834-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85007496834-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Morphology, Systematics and Phylogeny of Animals-
crisitem.author.orcid0000-0002-5864-8382-
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