Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/2949
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dc.contributor.authorChen, Nan Pengen_US
dc.contributor.authorUddin, Borhanen_US
dc.contributor.authorHardt, Roberten_US
dc.contributor.authorDing, Wenen_US
dc.contributor.authorPanić, Markoen_US
dc.contributor.authorLucibello, Ilariaen_US
dc.contributor.authorKammerer, Patriciaen_US
dc.contributor.authorRuppert, Thomasen_US
dc.contributor.authorSchiebel, Elmaren_US
dc.date.accessioned2019-10-29T17:31:08Z-
dc.date.available2019-10-29T17:31:08Z-
dc.date.issued2017-05-16-
dc.identifier.issn0027-8424-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/2949-
dc.description.abstractCDC14 is an essential dual-specificity phosphatase that counteracts CDK1 activity during anaphase to promote mitotic exit in Saccharomyces cerevisiae. Surprisingly, human CDC14A is not essential for cell cycle progression. Instead, it regulates cell migration and cell adhesion. Little is known about the substrates of hCDC14A and the counteracting kinases. Here, we combine phospho-proteome profiling and proximity-dependent biotin identification to identify hCDC14A substrates. Among these targets were actin regulators, including the tumor suppressor eplin. hCDC14A counteracts EGFinduced rearrangements of actin cytoskeleton by dephosphorylating eplin at two known extracellular signal-regulated kinase sites, serine 362 and 604. hCDC14APD and eplin knockout cell lines exhibited down-regulation of E-cadherin and a reduction in α/β-catenin at cell-cell adhesions. Reduction in the levels of hCDC14A and eplin mRNA is frequently associated with colorectal carcinoma and is correlated with poor prognosis. We therefore propose that eplin dephosphorylation by hCDC14A reduces actin dynamics to restrict tumor malignancy.en_US
dc.language.isoenen_US
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_US
dc.subjectActin dynamicsen_US
dc.subjectCDC14en_US
dc.subjectEplinen_US
dc.titleHuman phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasmen_US
dc.typeArticleen_US
dc.identifier.doi10.1073/pnas.1619356114-
dc.identifier.pmid28465438-
dc.identifier.scopus2-s2.0-85019943509-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85019943509-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Biochemistry and Molecular Biology-
Appears in Collections:Journal Article
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