Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/2919
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dc.contributor.authorPejin, Borisen_US
dc.contributor.authorStošić-Grujičić, Stanislavaen_US
dc.contributor.authorBogdanović, Gordanaen_US
dc.contributor.authorHegediš, Aleksandaren_US
dc.contributor.authorKaraman, Ivoen_US
dc.contributor.authorStojanović, Ivana D.en_US
dc.contributor.authorNikolic, Ivanaen_US
dc.contributor.authorKojić, Vesnaen_US
dc.contributor.authorHorvatović, Mladenen_US
dc.contributor.authorRadotić, Ksenijaen_US
dc.date.accessioned2019-10-29T15:01:13Z-
dc.date.available2019-10-29T15:01:13Z-
dc.date.issued2012-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/2919-
dc.description.abstractThe immunomodulatory and anticarcinogenic activity of the freshwater bryozoan Hyalinella punctata methanolic extract (MEx) was evaluated in vitro on selected biosystems for the first time. Murine lymphocytes and macrophages were used for testing of MEx effects on cell proliferation and nitric oxide (NO) production, respectively, while human cancer cell lines were utilized for measuring its activity against cancer cells. The results suggest a strong and tissue-specific immunomodifying activity (IC50 values for inhibition of proliferation of lymph node and spleen-derived lymphocytes were 4.1 μg/ml and 9.7 μg/ml, respectively) and moderate anticancer activity of MEx (IC50 value for the MCF-7 cell line was 24.13 μg/ml). Down-regulation of macrophage NO production was also obtained. The potential use of H. punctata-derived natural products for the treatment of human chronic inflammatory diseases and cancer is worthy of further investigation.en_US
dc.language.isoenen_US
dc.relation.ispartofDigest Journal of Nanomaterials and Biostructuresen_US
dc.subjectLymphocytesen_US
dc.subjectMacrophagesen_US
dc.subjectMCF-7 cellsen_US
dc.subjectNitric oxideen_US
dc.subjectProliferationen_US
dc.titleIn vitro evaluation of the immunomodulatory and anticarcinogenic activity of the freshwater bryozoan Hyalinella punctata methanolic extracten_US
dc.typeArticleen_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Animal Ecology and Zoogeography-
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