Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/271
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dc.contributor.authorStacchiotti, Alessandraen_US
dc.contributor.authorFavero, Gaiaen_US
dc.contributor.authorGiugno, Lorenaen_US
dc.contributor.authorGolić, Igoren_US
dc.contributor.authorKorać, Aleksandraen_US
dc.contributor.authorRezzani, Ritaen_US
dc.date.accessioned2019-06-28T12:40:52Z-
dc.date.available2019-06-28T12:40:52Z-
dc.date.issued2017-12-05-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/271-
dc.description.abstractCardiomyocytes are particularly sensitive to oxidative damage due to the link between mitochondria and sarcoplasmic reticulum necessary for calcium flux and contraction. Melatonin, important indoleamine secreted by the pineal gland during darkness, also has important cardioprotective properties. We designed the present study to define morphological and ultrastructural changes in cardiomyocytes and mainly in mitochondria of an animal model of obesity (ob/ob mice), when treated orally or not with melatonin at 100 mg/kg/day for 8 weeks (from 5 up to 13 week of life). We observed that ob/ob mice mitochondria in sub-sarcolemmal and inter-myofibrillar compartments are often devoid of cristae with an abnormally large size, which are called mega-mitochondria. Moreover, in ob/ob mice the hypertrophic cardiomyocytes expressed high level of 4hydroxy-2-nonenal (4HNE), a marker of lipid peroxidation but scarce degree of mitofusin2, indicative of mitochondrial sufferance. Melatonin oral supplementation in ob/ob mice restores mitochondrial cristae, enhances mitofusin2 expression and minimizes 4HNE and p62/SQSTM1, an index of aberrant autophagic flux. At pericardial fat level, adipose tissue depot strictly associated with myocardium infarction, melatonin reduces adipocyte hypertrophy and inversely regulates 4HNE and adiponectin expressions. In summary, melatonin might represent a safe dietary adjuvant to hamper cardiac mitochondria remodeling and the hypoxic status that occur in pre-diabetic obese mice at 13 weeks of life.en_US
dc.language.isoenen_US
dc.relationWhite or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disordersen_US
dc.relation.ispartofNutrientsen_US
dc.subjectLeptin-deficient miceen_US
dc.subjectLipid peroxidationen_US
dc.subjectMelatoninen_US
dc.subjectMitochondriaen_US
dc.subjectPericardial faten_US
dc.titleMelatonin efficacy in obese leptin-deficient mice hearten_US
dc.typeArticleen_US
dc.identifier.doi10.3390/nu9121323-
dc.identifier.pmid29206172-
dc.identifier.scopus2-s2.0-85037633283-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85037633283-
dc.description.rankM21en_US
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.deptChair of Cell and Tissue Biology-
crisitem.author.orcid0000-0001-5944-5053-
crisitem.author.orcid0000-0002-3044-9963-
crisitem.project.funderMESTD-
crisitem.project.grantno173055-
crisitem.project.fundingProgramBasic Research (BR or ON)-
crisitem.project.openAireinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173055-
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