Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/2523
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dc.contributor.authorNikčević, G.en_US
dc.contributor.authorKovačević-Grujičić, N.en_US
dc.contributor.authorMojsin, M.en_US
dc.contributor.authorKrstić, A.en_US
dc.contributor.authorSavić, T.en_US
dc.contributor.authorStevanović, Milenaen_US
dc.date.accessioned2019-10-24T16:48:27Z-
dc.date.available2019-10-24T16:48:27Z-
dc.date.issued2011-07-19-
dc.identifier.issn0862-8408-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/2523-
dc.description.abstractSox3/SOX3 gene is considered to be one of the earliest neural markers in vertebrates. Despite the mounting evidence that Sox3/SOX3 is one of the key players in the development of the nervous system, limited data are available regarding the transcriptional regulation of its expression. This review is focused on the retinoic acid induced regulation of SOX3 gene expression, with particular emphasis on the involvement of retinoid receptors. Experiments with human embryonal carcinoma cells identified two response elements involved in retinoic acid/retinoid X receptor-dependent activation of the SOX3 gene expression: distal atypical retinoic acid-response element, consisting of two unique G-rich boxes separated by 49 bp, and proximal element comprising DR-3-like motif, composed of two imperfect hexameric half-sites. Importantly, the retinoic acid-induced SOX3 gene expression could be significantly down-regulated by a synthetic antagonist of retinoid receptors. This cell model provides a solid base for further studies on mechanism(s) underlying regulation of expression of SOX3 gene, which could improve the understanding of molecular signals that induce neurogenesis in the stem/progenitor cells both during development and in adulthood. © 2011 Institute of Physiology v.v.i., Academy of Sciences of the Czech Republic, Prague, Czech Republic.en_US
dc.language.isoenen_US
dc.relation.ispartofPhysiological Researchen_US
dc.subjectEmbryonal carcinoma cellsen_US
dc.subjectNeuronal differentiationen_US
dc.subjectRetinoic aciden_US
dc.subjectRetinoid receptorsen_US
dc.subjectSOX3en_US
dc.titleRegulation of the SOX3 gene expression by retinoid receptorsen_US
dc.typeArticleen_US
dc.identifier.pmid21777018-
dc.identifier.scopus2-s2.0-84856593300-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/84856593300-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Biochemistry and Molecular Biology-
crisitem.author.orcid0000-0003-4286-7334-
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