Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/243
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dc.contributor.authorCvijić, Gordanaen_US
dc.contributor.authorPetrović, Natašaen_US
dc.contributor.authorĐorđević, Jelenaen_US
dc.contributor.authorDavidović, Vukosavaen_US
dc.contributor.authorPetrović, Vojislaven_US
dc.date.accessioned2019-06-28T07:00:35Z-
dc.date.available2019-06-28T07:00:35Z-
dc.date.issued2004-01-01-
dc.identifier.issn0077-8923-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/243-
dc.description.abstractAs the indicators of sympathetic nervous system (SNS) function, the activity of serum dopamine-β-hydroxytase (DBII) and interscaputar brown adipose tissue (IBAT) monoamine oxidase (MAO) were examined in rats that were chemically thyroidectomized (TX), treated with thyroid hormones, and exposed to cold (4°C). In TX animals, body temperature (bt) significantly decreased, and relative IBAT mass increased as compared with control, euthyroid animals, independent of the ambient temperature. The bt fall in TX cold-exposed animals was more severe, provoking hypothermia after 4 h. Under the same experimental conditions, the SNS function was enhanced as judged by the increased serum DBH and IBAT MAO activities. The treatment of TX animals with T4 and T3 re-established the temperature (bt was at the level of controls) and sympathetic homeostasis (DBH activity was at the level of controls) in animals maintained at room temperature but not in those kept under cold conditions. T4 and T3 did not affect IBAT MAO activity of TX rats: It remained significantly above the control values whether the animals were maintained at room temperature or exposed to cold. In conclusion, the IBAT of TX cold-exposed rats is incapable of responding to the enhanced thermogenic needs despite the increased SNS activity and thyroid hormone substitution.en_US
dc.language.isoenen_US
dc.relation.ispartofAnnals of the New York Academy of Sciencesen_US
dc.subjectColden_US
dc.subjectDBHen_US
dc.subjectIBATen_US
dc.subjectMAOen_US
dc.subjectT3en_US
dc.subjectT4en_US
dc.titleEffect of cold exposure on serum DBH and interscapular brown adipose tissue MAO activity in hypothyroid T<inf>3</inf>- And T<inf>4</inf>-treated ratsen_US
dc.typeArticleen_US
dc.identifier.doi10.1196/annals.1296.025-
dc.identifier.pmid15240371-
dc.identifier.scopus2-s2.0-3242718542-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/3242718542-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.orcid0000-0002-6510-1027-
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