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Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/2400
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dc.contributor.authorVidenović, Milicaen_US
dc.contributor.authorMojsin, Marijaen_US
dc.contributor.authorStevanović, Milenaen_US
dc.contributor.authorOpsenica, Igoren_US
dc.contributor.authorSrdić-Rajić, Tatjanaen_US
dc.contributor.authorŠolaja, Bogdanen_US
dc.date.accessioned2019-10-23T19:48:35Z-
dc.date.available2019-10-23T19:48:35Z-
dc.date.issued2018-09-05-
dc.identifier.issn0223-5234-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/2400-
dc.description.abstract© 2018 Elsevier Masson SAS A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, submicromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness.en_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Medicinal Chemistryen_US
dc.subjectAnoikisen_US
dc.subjectAntiproliferativeen_US
dc.subjectBenzothiazolesen_US
dc.subjectMCF-7en_US
dc.subjectNT2/D1en_US
dc.titleBenzothiazole carbamates and amides as antiproliferative speciesen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.ejmech.2018.08.067-
dc.identifier.pmid30179747-
dc.identifier.scopus2-s2.0-85054063702-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85054063702-
dc.description.rankM21a-
dc.description.impact6.514-
item.cerifentitytypePublications-
item.grantfulltextrestricted-
item.openairetypeArticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
crisitem.author.deptChair of Biochemistry and Molecular Biology-
crisitem.author.orcid0000-0003-4286-7334-
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