Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/187
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dc.contributor.authorSoskić, Sanjaen_US
dc.contributor.authorStokić, Editaen_US
dc.contributor.authorObradović, Milanen_US
dc.contributor.authorSudar, Eminaen_US
dc.contributor.authorTanić, Nastaen_US
dc.contributor.authorKupusinac, Aleksandaren_US
dc.contributor.authorĐorđević, Jelenaen_US
dc.contributor.authorIsenović, Esmaen_US
dc.date.accessioned2019-06-27T10:12:51Z-
dc.date.available2019-06-27T10:12:51Z-
dc.date.issued2014-01-01-
dc.identifier.issn1758-4299-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/187-
dc.description.abstractAim: The aim of this pilot study was to investigate possible associations of LEP promoter polymorphism LEP G-2548A and obesity-associated metabolic and antropometric parameters in obese population. Materials & methods: Group of 31 patients with hyperalimentary type of obesity (mean age: 39.26 ± 11.45 years; BMI: 41.51 ± 9.22 kg/m2) and 36 healthy, nonobese, normal weight subjects (mean age: 33.55 ± 6.46 years; BMI: 22.63 ± 1.94 kg/m2) were studied. Blood samples were collected for DNA isolation, serum leptin and serum lipids measurements. LEP G-2548A genotypes were determined by PCR restriction fragment length polymorphism based analyses. Results: No significant differences in genotype and allele frequencies of the LEP G-2548A polymorphism were detected between obese and normal weight subjects. No association was found between this polymorphism and BMI. Obese subjects had statistically significant increase in serum leptin levels compared with control, while no association between leptin concentration and LEP polymorphism LEP G-2548A was found. There is a statistically significant association of LEP G-2548A genotypes with LDL (p < 0.05), LDL/HDL ratio (p < 0.001), apoB (p < 0.01), body weight (p < 0.001) and waist circumference (p < 0.001). Conclusion: Our findings indicate that there is an association between LEP G-2548A polymorphism and metabolic and anthropometric parameters in obese patients in a Serbian population.en_US
dc.language.isoenen_US
dc.relation.ispartofClinical Lipidologyen_US
dc.subjectapo Ben_US
dc.subjectLEPen_US
dc.subjectlipoproteinen_US
dc.subjectobesityen_US
dc.subjectpolymorphismen_US
dc.titleAssociation of leptin gene polymorphism G-2548A with metabolic and anthropometric parameters in obese patients in a Serbian population: Pilot studyen_US
dc.typeArticleen_US
dc.identifier.doi10.2217/clp.14.42-
dc.identifier.scopus2-s2.0-84914179566-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/84914179566-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.orcid0000-0002-6510-1027-
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