Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/1592
DC Field | Value | Language |
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dc.contributor.author | Veličković, Nataša | en_US |
dc.contributor.author | Teofilović, Ana | en_US |
dc.contributor.author | Ilić, Dragana | en_US |
dc.contributor.author | Djordjevic, Ana | en_US |
dc.contributor.author | Vojnović Milutinović, Danijela | en_US |
dc.contributor.author | Petrović, Snježana | en_US |
dc.contributor.author | Preitner, Frederic | en_US |
dc.contributor.author | Tappy, Luc | en_US |
dc.contributor.author | Matić, Gordana | en_US |
dc.date.accessioned | 2019-10-09T07:22:14Z | - |
dc.date.available | 2019-10-09T07:22:14Z | - |
dc.date.issued | 2019-08-01 | - |
dc.identifier.issn | 1436-6207 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/1592 | - |
dc.description.abstract | © 2018, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: High-fructose consumption and chronic stress are both associated with metabolic inflammation and insulin resistance. Recently, disturbed activity of energy sensor AMP-activated protein kinase (AMPK) was recognized as mediator between nutrient-induced stress and inflammation. Thus, we analyzed the effects of high-fructose diet, alone or in combination with chronic stress, on glucose homeostasis, inflammation and expression of energy sensing proteins in the rat liver. Methods: In male Wistar rats exposed to 9-week 20% fructose diet and/or 4-week chronic unpredictable stress we measured plasma and hepatic corticosterone level, indicators of glucose homeostasis and lipid metabolism, hepatic inflammation (pro- and anti-inflammatory cytokine levels, Toll-like receptor 4, NLRP3, activation of NFκB, JNK and ERK pathways) and levels of energy-sensing proteins AMPK, SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α). Results: High-fructose diet led to glucose intolerance, activation of NFκB and JNK pathways and increased intrahepatic IL-1β, TNFα and inhibitory phosphorylation of insulin receptor substrate 1 on Ser307. It also decreased phospho-AMPK/AMPK ratio and increased SIRT1 expression. Stress alone increased plasma and hepatic corticosterone but did not influence glucose tolerance, nor hepatic inflammatory or energy-sensing proteins. After the combined treatment, hepatic corticosterone was increased, glucose tolerance remained preserved, while hepatic inflammation was partially prevented despite decreased AMPK activity. Conclusion: High-fructose diet resulted in glucose intolerance, hepatic inflammation, decreased AMPK activity and reduced insulin sensitivity. Chronic stress alone did not exert such effects, but when applied together with high-fructose diet it could partially prevent fructose-induced inflammation, presumably due to increased hepatic glucocorticoids. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | European Journal of Nutrition | en_US |
dc.subject | AMP-activated protein kinase | en_US |
dc.subject | Dietary fructose | en_US |
dc.subject | Inflammation | en_US |
dc.subject | Rat liver | en_US |
dc.subject | Stress | en_US |
dc.title | Modulation of hepatic inflammation and energy-sensing pathways in the rat liver by high-fructose diet and chronic stress | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1007/s00394-018-1730-1 | - |
dc.identifier.pmid | 29845385 | - |
dc.identifier.scopus | 2-s2.0-85047661903 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85047661903 | - |
dc.description.rank | M21 | - |
dc.description.impact | 4.664 | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | restricted | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Biochemistry and Molecular Biology | - |
crisitem.author.orcid | 0000-0002-0142-1056 | - |
Appears in Collections: | Journal Article |
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File | Description | Size | Format | Existing users please |
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Velickovic-EurJNutr-2018.pdf | Velickovic-EurJNutr-2018 | 1.91 MB | Adobe PDF | Request a copy |
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