Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1486
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dc.contributor.authorNerlich, Janaen_US
dc.contributor.authorKuenzel, Thomasen_US
dc.contributor.authorKeine, Christianen_US
dc.contributor.authorKorenić, Andrejen_US
dc.contributor.authorRübsamen, Rudolfen_US
dc.contributor.authorMilenkovic, Ivanen_US
dc.date.accessioned2019-09-27T15:14:20Z-
dc.date.available2019-09-27T15:14:20Z-
dc.date.issued2014-08-27-
dc.identifier.issn0270-6474-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/1486-
dc.description.abstractGABA and glycine are the major inhibitory transmitters that attune neuronal activity in the CNS of mammals. The respective transmitters are mostly spatially separated, that is, synaptic inhibition in the forebrain areas is mediated by GABA, whereas glycine is predominantly used in the brainstem. Accordingly, inhibition in auditory brainstem circuits is largely mediated by glycine, but there are few auditory synapses using both transmitters in maturity. Little is known about physiological advantages of such a two-transmitter inhibitory mechanism. We explored the benefit of engaging both glycine and GABA with inhibition at the endbulb of Held-spherical bushy cell synapse in the auditory brainstem of juvenile Mongolian gerbils. This model synapse enables selective in vivo activation of excitatory and inhibitory neuronal inputs through systemic sound stimulation and precise analysis of the input (endbulb of Held) output (spherical bushy cell) function. The combination of in vivo and slice electrophysiology revealed that the dynamic AP inhibition in spherical bushy cells closely matches the inhibitory conductance profile determined by the glycine-R and GABAA-R. The slow and potent glycinergic component dominates the inhibitory conductance, thereby primarily accounting for its high-pass filter properties. GABAergic transmission enhances the inhibitory strength and shapes its duration in an activity-dependent manner, thus increasing the inhibitory potency to suppress the excitation through the endbulb of Held. Finally, in silico modeling provides a strong link between in vivo and slice data by simulating the interactions between the endbulb- and the synergistic glycine-GABA-conductances during in vivo-like spontaneous and sound evoked activities. © 2014 the authors.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Neuroscienceen_US
dc.subjectAP inhibitionen_US
dc.subjectAuditory signal processingen_US
dc.subjectGABAA/glycine receptorsen_US
dc.subjectIn vivo electrophysiologyen_US
dc.subjectModelingen_US
dc.subjectSlice electrophysiologyen_US
dc.titleDynamic fidelity control to the central auditory system: Synergistic glycine/GABAergic inhibition in the cochlear nucleusen_US
dc.typeArticleen_US
dc.identifier.doi10.1523/JNEUROSCI.0719-14.2014-
dc.identifier.pmid25164657-
dc.identifier.scopus2-s2.0-84906569337-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/84906569337-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.orcid0000-0001-9476-7445-
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