Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1431
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dc.contributor.authorBerić, Tanjaen_US
dc.contributor.authorNikolić, Biljanaen_US
dc.contributor.authorStanojević, Jasnaen_US
dc.contributor.authorVuković Gačić, Brankaen_US
dc.contributor.authorKnežević Vukčević, Jelenaen_US
dc.date.accessioned2019-09-26T09:58:50Z-
dc.date.available2019-09-26T09:58:50Z-
dc.date.issued2008-02-01-
dc.identifier.issn0278-6915-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/1431-
dc.description.abstractMutagenic and antimutagenic properties of essential oil (EO) of basil and its major constituent Linalool, reported to possess antioxidative properties, were examined in microbial tests. In Salmonella/microsome and Escherichia. coli WP2 reversion assays both derivatives (0.25-2.0 μl/plate) showed no mutagenic effect. Salmonella. typhimurium TA98, TA100 and TA102 strains displayed similar sensitivity to both basil derivatives as non-permeable E. coli WP2 strains IC185 and IC202 oxyR. Moreover, the toxicity of basil derivatives to WP2 strains did not depend on OxyR function. The reduction of t-BOOH-induced mutagenesis by EO and Linalool (30-60%) was obtained in repair proficient strains of the E. coli K12 assay (Nikolić, B., Stanojević, J., Mitić, D., Vuković-Gačić, B., Knežević-Vukčević, J., Simić, D., 2004. Comparative study of the antimutagenic potential of vitamin E in different E. coli strains. Mutat. Res. 564, 31-38), as well as in E. coli WP2 IC202 strain. EO and Linalool reduced spontaneous mutagenesis in mismatch repair deficient E. coli K12 strains (27-44%). In all tests, antimutagenic effect of basil derivatives was comparable with that obtained with model antioxidant vitamin E. Linalool and vitamin E induced DNA strand breaks in Comet assay on S. cerevisiae 3A cells, but at non-genotoxic concentrations (0.075 and 0.025 μg/ml, respectively) they reduced the number of H2O2-induced comets (45-70% Linalool and 80-93% vitamin E). Obtained results indicate that antigenotoxic potential of basil derivatives could be attributed to their antioxidative properties. © 2007 Elsevier Ltd. All rights reserved.en_US
dc.language.isoenen_US
dc.relation.ispartofFood and Chemical Toxicologyen_US
dc.subjectBasilen_US
dc.subjectYeast comet assayen_US
dc.subjectReversion testsen_US
dc.subjectOxidative DNA damageen_US
dc.titleProtective effect of basil (Ocimum basilicum L.) against oxidative DNA damage and mutagenesisen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.fct.2007.09.102-
dc.identifier.pmid17980946-
dc.identifier.scopus2-s2.0-37449033286-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/37449033286-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeArticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.deptChair of Microbiology-
crisitem.author.orcid0000-0002-4860-2225-
crisitem.author.orcid0000-0003-1765-2454-
crisitem.author.orcid0000-0001-8767-1912-
crisitem.author.orcid0000-0002-8138-6579-
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