Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/140
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Stančić, Ana | en_US |
dc.contributor.author | Otašević, Vesna | en_US |
dc.contributor.author | Janković, Aleksandra | en_US |
dc.contributor.author | Vučetić, Milica | en_US |
dc.contributor.author | Ivanović-Burmazović, Ivana | en_US |
dc.contributor.author | Filipović, Miloš R. | en_US |
dc.contributor.author | Korać, Aleksandra | en_US |
dc.contributor.author | Markelić, Milica | en_US |
dc.contributor.author | Veličković, Ksenija | en_US |
dc.contributor.author | Golić, Igor | en_US |
dc.contributor.author | Buzadžić, Biljana | en_US |
dc.contributor.author | Korać, Bato | en_US |
dc.date.accessioned | 2019-06-20T13:52:18Z | - |
dc.date.available | 2019-06-20T13:52:18Z | - |
dc.date.issued | 2013-10-01 | - |
dc.identifier.issn | 0361-9230 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/140 | - |
dc.description.abstract | Hippocampal structural changes associated with diabetes-related cognitive impairments are well described, but their molecular background remained vague. We examined whether/how diabetes alters molecular basis of energy metabolism in hippocampus readily after diabetes onset, with special emphasis on its redox-sensitivity.To induce diabetes, adult Mill Hill hybrid hooded rats received a single alloxan dose (120mg/kg). Both non-diabetic and diabetic groups were further divided in two subgroups receiving (i) or not (ii) superoxide dismutase (SOD) mimic, [Mn(II)(pyane)Cl2] for 7 days, i.p. Treatment of the diabetic animals started after blood glucose level ≥12mM.Diabetes decreased protein levels of oxidative phosphorylation components: complex III and ATP synthase. In contrast, protein amounts of glyceraldehyde-3-phosphate dehydrogenase, pyruvate dehydrogenase, and hypoxia-inducible factor-1α - the key regulator of energy metabolism in stress conditions, were higher in diabetic animals. Treatment with SOD mimic restored/increased the levels of oxidative phosphorylation components and returned hypoxia-inducible factor-1α to control level, while diabetes-induced up-regulation of glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase, was additionally stimulated.To conclude, our results provide insight into the earliest molecular changes of energy-producing pathways in diabetes that may account for structural/functional disturbance of hippocampus, seen during disease progression. Also, data suggest [Mn(II)(pyane)Cl2] as potential therapeutic agent in cutting-edge approaches to threat this widespread metabolic disorder. © 2013 Elsevier Inc. | en_US |
dc.language.iso | en | en_US |
dc.relation | White or/and brown: importance of adipose tissue in overall redox dependent metabolic control in physiological adaptations and metabolic disorders | en_US |
dc.relation.ispartof | Brain Research Bulletin | en_US |
dc.subject | Diabetes | en_US |
dc.subject | Glycolysis | en_US |
dc.subject | hippocampus | en_US |
dc.subject | Oxidative phosphorylation | en_US |
dc.subject | SOD mimic | en_US |
dc.title | Molecular basis of hippocampal energy metabolism in diabetic rats: The effects of SOD mimic | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1016/j.brainresbull.2013.09.009 | - |
dc.identifier.pmid | 24084255 | - |
dc.identifier.scopus | 2-s2.0-84886067343 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84886067343 | - |
dc.description.rank | M22 | en_US |
dc.description.impact | 2.974 | en_US |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Cell and Tissue Biology | - |
crisitem.author.dept | Chair of Cell and Tissue Biology | - |
crisitem.author.dept | Chair of Cell and Tissue Biology | - |
crisitem.author.dept | Chair of Cell and Tissue Biology | - |
crisitem.author.orcid | 0000-0002-3044-9963 | - |
crisitem.author.orcid | 0000-0002-5444-7735 | - |
crisitem.author.orcid | 0000-0002-4373-5483 | - |
crisitem.author.orcid | 0000-0001-5944-5053 | - |
crisitem.author.orcid | 0000-0001-5272-579X | - |
crisitem.project.funder | MESTD | - |
crisitem.project.grantno | 173055 | - |
crisitem.project.fundingProgram | Basic Research (BR or ON) | - |
crisitem.project.openAire | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173055 | - |
Appears in Collections: | Journal Article |
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