Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/121
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dc.contributor.authorCvijić, Gordanaen_US
dc.contributor.authorLakić, Ivaen_US
dc.contributor.authorVujović, Predragen_US
dc.contributor.authorJasnić, Nebojšaen_US
dc.contributor.authorĐurašević, Sinišaen_US
dc.contributor.authorDronjak-Čučaković, Slađanaen_US
dc.contributor.authorĐorđević, Jelenaen_US
dc.date.accessioned2019-06-20T11:49:55Z-
dc.date.available2019-06-20T11:49:55Z-
dc.date.issued2013-08-27-
dc.identifier.issn0354-4664-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/121-
dc.description.abstractThe aim of this study was to examine whether the thermogenic potential of rat interscapular brown adipose tissue (IBAT) changes in response to acute and/or chronic exposure to non-thermal stressors (immobilization and isolation), by measuring the uncoupling protein 1 (UCP-1) content, MAO-A, SOD and CAT activities, as well as the number of IBAT sympathetic noradrenaline-containing nerve fibers. Both acute immobilization (2 h) and chronic isolation (21 days), as well as their combined effects, significantly increased the IBAT UCP-1 content in comparison to non-stressed animals. When applied individually, stressors increased the number of sympathetic fibers in comparison to controls, whereas in combination they decreased it. The activity of IBAT monoamine oxidase-A (MAO-A) decreased under the influence of each stressor independent of its type or duration. SOD activity coincided with MAO-A decrement, whereas CAT activity had an opposite pattern of changes. We conclude that acute and chronic exposure to non-thermal stressors, immobilization and isolation, respectively, affect the metabolic potential of rat IBAT, judging by the increase in UCP-1 content and sympathetic outflow. However, when acute immobilization was applied as a novel stressor to previously chronically isolated animals, an increase in the UCP-1 content was accompanied by a lower IBAT sympathetic outflow, suggesting that IBAT metabolic function under various stress condition is not solely dependent on SNS activity.en_US
dc.language.isoenen_US
dc.relation.ispartofArchives of Biological Sciencesen_US
dc.subjectCatalaseen_US
dc.subjectIBATen_US
dc.subjectImmobilizationen_US
dc.subjectIsolationen_US
dc.subjectMAO-Aen_US
dc.subjectSODen_US
dc.subjectUCP-1en_US
dc.titleSingle and combined effects of acute and chronic non-thermal stressors on rat interscapular brown adipose tissue metabolic activityen_US
dc.typeArticleen_US
dc.identifier.doi10.2298/ABS1303919C-
dc.identifier.scopus2-s2.0-84882616747-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/84882616747-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.grantfulltextrestricted-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.orcid0000-0001-8894-7300-
crisitem.author.orcid0000-0002-9444-4758-
crisitem.author.orcid0000-0003-0333-333X-
crisitem.author.orcid0000-0003-4406-8376-
crisitem.author.orcid0000-0002-6510-1027-
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