Please use this identifier to cite or link to this item:
https://biore.bio.bg.ac.rs/handle/123456789/121
DC Field | Value | Language |
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dc.contributor.author | Cvijić, Gordana | en_US |
dc.contributor.author | Lakić, Iva | en_US |
dc.contributor.author | Vujović, Predrag | en_US |
dc.contributor.author | Jasnić, Nebojša | en_US |
dc.contributor.author | Đurašević, Siniša | en_US |
dc.contributor.author | Dronjak-Čučaković, Slađana | en_US |
dc.contributor.author | Đorđević, Jelena | en_US |
dc.date.accessioned | 2019-06-20T11:49:55Z | - |
dc.date.available | 2019-06-20T11:49:55Z | - |
dc.date.issued | 2013-08-27 | - |
dc.identifier.issn | 0354-4664 | - |
dc.identifier.uri | https://biore.bio.bg.ac.rs/handle/123456789/121 | - |
dc.description.abstract | The aim of this study was to examine whether the thermogenic potential of rat interscapular brown adipose tissue (IBAT) changes in response to acute and/or chronic exposure to non-thermal stressors (immobilization and isolation), by measuring the uncoupling protein 1 (UCP-1) content, MAO-A, SOD and CAT activities, as well as the number of IBAT sympathetic noradrenaline-containing nerve fibers. Both acute immobilization (2 h) and chronic isolation (21 days), as well as their combined effects, significantly increased the IBAT UCP-1 content in comparison to non-stressed animals. When applied individually, stressors increased the number of sympathetic fibers in comparison to controls, whereas in combination they decreased it. The activity of IBAT monoamine oxidase-A (MAO-A) decreased under the influence of each stressor independent of its type or duration. SOD activity coincided with MAO-A decrement, whereas CAT activity had an opposite pattern of changes. We conclude that acute and chronic exposure to non-thermal stressors, immobilization and isolation, respectively, affect the metabolic potential of rat IBAT, judging by the increase in UCP-1 content and sympathetic outflow. However, when acute immobilization was applied as a novel stressor to previously chronically isolated animals, an increase in the UCP-1 content was accompanied by a lower IBAT sympathetic outflow, suggesting that IBAT metabolic function under various stress condition is not solely dependent on SNS activity. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Archives of Biological Sciences | en_US |
dc.subject | Catalase | en_US |
dc.subject | IBAT | en_US |
dc.subject | Immobilization | en_US |
dc.subject | Isolation | en_US |
dc.subject | MAO-A | en_US |
dc.subject | SOD | en_US |
dc.subject | UCP-1 | en_US |
dc.title | Single and combined effects of acute and chronic non-thermal stressors on rat interscapular brown adipose tissue metabolic activity | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.2298/ABS1303919C | - |
dc.identifier.scopus | 2-s2.0-84882616747 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/84882616747 | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | restricted | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | Chair of Comparative Physiology and Ecophysiology | - |
crisitem.author.dept | Chair of Comparative Physiology and Ecophysiology | - |
crisitem.author.dept | Chair of Comparative Physiology and Ecophysiology | - |
crisitem.author.dept | Chair of Comparative Physiology and Ecophysiology | - |
crisitem.author.dept | Chair of Comparative Physiology and Ecophysiology | - |
crisitem.author.orcid | 0000-0001-8894-7300 | - |
crisitem.author.orcid | 0000-0002-9444-4758 | - |
crisitem.author.orcid | 0000-0003-0333-333X | - |
crisitem.author.orcid | 0000-0003-4406-8376 | - |
crisitem.author.orcid | 0000-0002-6510-1027 | - |
Appears in Collections: | Journal Article |
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2013_Single and combined effects of acute and chronic non-thermal stressors on rat interscapular brown adipose tissue metabolic activity.PDF | 16.49 MB | Adobe PDF | Request a copy |
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