Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/1102
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dc.contributor.authorKrcunović, Zoricaen_US
dc.contributor.authorNovaković, Ivanaen_US
dc.contributor.authorMaksimović, Nelaen_US
dc.contributor.authorBukvić, Danicaen_US
dc.contributor.authorSimić-Ogrizović, Sanjaen_US
dc.contributor.authorJanković, Slavenkaen_US
dc.contributor.authorDsaraukanović, Ljubicaen_US
dc.contributor.authorCvetković, Draganaen_US
dc.date.accessioned2019-07-24T12:14:51Z-
dc.date.available2019-07-24T12:14:51Z-
dc.date.issued2010-12-01-
dc.identifier.issn0354-4664-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/1102-
dc.description.abstractBalkan endemic nephropathy (BEN) was recognized as a distinct entity more than 50 years ago, but the exact environmental and genetic causes of the disease remain elusive. Considering the role of the renin-angiotensin system (RAS) in the emergence of various nephropathies, in the present study we evaluated the possible association with BEN of polymorphisms in two RAS genes: I/D ACE (an angiotensin-converting enzyme) and A1166C AT1R (an angiotensin type 1 receptor). The study groups consisted of 48 BEN patients from the endemic region in the district of Kolubara, Serbia, 33 patients with other nephropathies and 42 healthy individuals. The ACE DD genotype was significantly more represented in the NBEN group (OR=5.447; 95%CI=1.862-15.932, p<0.01). The frequency of the AT1R CC genotype was higher in BEN patients compared to controls (0.104 vs. 0.048), but the difference was not significant. Though the analyzed polymorphisms are associated with certain nephropathies, we found no support for their specific role in BEN susceptibility.en_US
dc.language.isoenen_US
dc.relation.ispartofArchives of Biological Sciencesen_US
dc.subjectACE I/Den_US
dc.subjectAT1R A1166Cen_US
dc.subjectBalkan endemic nephropathyen_US
dc.subjectCandidate gene polymorphismen_US
dc.subjectRAS systemen_US
dc.titleGenetic clues to the etiology of balkan endemic nephropathy: Investigating the role of ace and at1r polymorphismsen_US
dc.typeArticleen_US
dc.identifier.doi10.2298/ABS1004957K-
dc.identifier.scopus2-s2.0-78650980757-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/78650980757-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Genetics and Evolution-
crisitem.author.orcid0000-0002-1311-7481-
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