Please use this identifier to cite or link to this item: http://biore.bio.bg.ac.rs/handle/123456789/1064
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dc.contributor.authorLaketa, Danijelaen_US
dc.contributor.authorBjelobaba, Ivanaen_US
dc.contributor.authorStojkov, Danijelaen_US
dc.contributor.authorLavrnja, Irenaen_US
dc.contributor.authorParabucki, Anaen_US
dc.contributor.authorStojiljković, Mirjanaen_US
dc.contributor.authorNedeljković, Nadeždaen_US
dc.date.accessioned2019-07-23T13:21:17Z-
dc.date.available2019-07-23T13:21:17Z-
dc.date.issued2013-02-06-
dc.identifier.issn03544664-
dc.identifier.urihttp://hdl.handle.net/123456789/1064-
dc.description.abstractInjury and other pathological conditions induce a massive release of ATP and ADP that initiate an immune response. Extracellular nucleotides are degraded by ectonucleotidases: enzymes from E-NTPDase and E-NPP families sequentially hydrolyze ATP and ADP to AMP, which is further hydrolyzed by ecto-5'-nucleotidase to adenosine that exerts suppressive effects on immune cells. We investigated the ectonucleotidase activities of peripheral lymphocytes at different post-injury times after an unilateral brain injury in the rat. Significant and dynamic changes in the lymphocytic ectonucleotidase activities were obtained. ATP- and ADP-hydrolysis changes, together with their calculated ratios, indicate the major contribution of E-NTPDase 1 and its comparable upregulation between sham operation and injury. AMP hydrolysis changes were more brain-injury specific, with a longer-lasting lymphocytic response induced by cortical stab injury (CSI). In summary, CSI and sham operation induce the upregulation of the whole enzyme chain for adenine nucleotide hydrolysis in lymphocytes, suggesting an important roles of ectonucleotidases in the course of recovery after brain injury.en_US
dc.relation.ispartofArchives of Biological Sciencesen_US
dc.subjectAdenosineen_US
dc.subjectADPen_US
dc.subjectATPen_US
dc.subjectE-NTPDaseen_US
dc.subjectEcto-5'-nucleotidase brain injuryen_US
dc.titleBrain cortical injury induces changes in peripheral lymphocyte ectonucleotidase activitiesen_US
dc.typeArticleen_US
dc.identifier.doi10.2298/ABS1301033L-
dc.identifier.scopus2-s2.0-84873169444-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/84873169444-
item.grantfulltextrestricted-
item.fulltextWith Fulltext-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.deptChair of General Physiology and Biophysics-
crisitem.author.orcid0000-0002-6563-8924-
crisitem.author.orcid0000-0003-3046-0983-
Appears in Collections:Journal Article
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