Please use this identifier to cite or link to this item: https://biore.bio.bg.ac.rs/handle/123456789/100
DC FieldValueLanguage
dc.contributor.authorRadojičić, Ratkoen_US
dc.contributor.authorCvijić, Gordanaen_US
dc.contributor.authorĐorđević, Jelenaen_US
dc.contributor.authorĐurašević, Sinišaen_US
dc.contributor.authorDavidović, Vukosavaen_US
dc.date.accessioned2019-06-19T20:37:34Z-
dc.date.available2019-06-19T20:37:34Z-
dc.date.issued1997-01-01-
dc.identifier.issn0742-8413-
dc.identifier.urihttps://biore.bio.bg.ac.rs/handle/123456789/100-
dc.description.abstractIt was shown that hydrogen peroxide (H 2 O 2 ) is a possible intracellular second messenger in specific insulin action. Because its concentration in the cell depends on the activity of both antioxidant enzymes and monoamine oxidase (MAO), we studied the influence of different insulin doses (0.4 and 4.0 IU/kg body mass, i.p., daily injected over 3 days) on the activity of MAO, types A and B, copper zinc superoxide dismutase (CuZnSOD), manganese superoxide dismutase (MnSOD), and catalase in the rat brainstem. Chronic insulin treatment significantly increased V(max) of MAO-A and B activities (P < 0.05, P < 0.025, respectively) independent of the dose applied. However, insulin had the opposite effect on MnSOD and catalase causing a decrease in their activities (P < 0.005). The observed changes in the activities of the enzymes studied are possible compensations that potentially maintain an optimal H 2 O 2 level in the brainstem, which might be important for insulin action.en_US
dc.language.isoenen_US
dc.relation.ispartofComparative Biochemistry and Physiology - C Pharmacology Toxicology and Endocrinologyen_US
dc.subjectBrainstemen_US
dc.subjectCatalaseen_US
dc.subjectInsulinen_US
dc.subjectMonoamino oxidaseen_US
dc.subjectSuperoxide dismutaseen_US
dc.titleChronic effect of insulin on monoamine oxidase and antioxidant enzyme activities in the rat brainstemen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/S0742-8413(97)89893-3-
dc.identifier.pmid9214720-
dc.identifier.scopus2-s2.0-0343145726-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/0343145726-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.deptChair of Comparative Physiology and Ecophysiology-
crisitem.author.orcid0000-0002-6510-1027-
crisitem.author.orcid0000-0003-4406-8376-
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